Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression
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چکیده
منابع مشابه
1 Hepatic TLR 4 signaling in Obese NAFLD
16 Nonalcoholic fatty liver disease (NAFLD) occurs frequently in the setting of metabolic syndrome, but the factors 17 leading to nonalcoholic steatohepatitis (NASH) are not fully understood. This study investigated toll-like 18 receptor 4 (TLR4) signaling in human liver with the goal of delineating whether activation of this pathway 19 segregates those with nonalcoholic fatty liver (NAFL) from...
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Iodothyronine deiodinase in vitro activity studies in the chicken showed the presence of type I and type III iodothyronine deiodinase activity in both liver and kidney. Due to the lack of a specific antiserum the cellular localization of the deiodinase proteins could not be revealed until now. In the present study, specific antisera were used to study the renal and hepatic distribution of type ...
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The iodothyronine deiodinases are selenoenzymes that regulate the activity of thyroid hormone via specific inner- or outer-ring deiodination. In humans, type 1 deiodinase (D1) is highly expressed in the liver, but the mechanism by which its gene expression is regulated remains to be elucidated. Liver X receptor α (LXRα), a transcription factor of the nuclear receptor superfamily, is highly expr...
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The major physiologic function of type 1 iodothyronine deiodinase (D1) is to produce triiodothyronine (T(3)) for the plasma. D1 activity is regulated by numerous factors, perhaps the most important of which in human pathophysiology is T(3). T(3) induces D1 expression, contributing to the T(3) excess commonly found in hyperthyroidism. Cytokines, nutritional status, sex steroids, and other factor...
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BACKGROUND The induction of tumor angiogenesis, a pathologic process critical for tumor progression, is mediated by multiple regulatory factors released by tumor and host cells. We investigated the role of the hematopoietic cytokine erythropoietin as an angiogenic factor that modulates tumor progression. METHODOLOGY/PRINCIPAL FINDINGS Fluorescently-labeled rodent mammary carcinoma cells were ...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2021
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2021.101266